Fig. 4: Late-stage diversification of drug molecules and natural products.
From: Enantioselective synthesis of N-alkylindoles enabled by nickel-catalyzed C-C coupling
Conditions: All reactions were carried out with NiI2•xH2O (10 mol%), ligand L*1 (15 mol%), 1a or citronellal-derived 1u (0.40 mmol), drugs- or ntural products-derived 2 (0.80 mmol), (OEt)2MeSiH (0.48 or 0.72 mmol), KF (0.60 or 0.88 mmol) and DME/DCE (3:1, 2.0 mL) at room temperature for 20 or 48 h.
