Fig. 1: Social stress increases palatable food intake. | Nature Communications

Fig. 1: Social stress increases palatable food intake.

From: Stress-driven potentiation of lateral hypothalamic synapses onto ventral tegmental area dopamine neurons causes increased consumption of palatable food

Fig. 1

a Timeline and schematic for social stress protocol followed by ad libitum High Fat High Sugar (HFHS) diet or limited fat access paradigm (Binge: 2 h fat, 22 h chow). b Ad libitum HFHS diet; Fat intake in kcals per day increased post stress day (PSD) 1 and 2 (n group = 17, RM Two-way ANOVA. Main effect stress F(1,32) = 18.44, p = 0.0002; PSD1 F(1,32) = 11.19, p = 0.002; PSD2 F(1,32) = 10.40, p = 0.003). c Ad libitum HFHS diet; Sugar water intake in kcals per day increased post stress (n group = 17, RM Two-way ANOVA. Main effect stress F(1,32) = 8.95, p = 0.005; PSD1 F(1,32) = 6.39, p = 0.017; PSD2 F(1,32) = 9.54, p = 0.004). d Ad libitum HFHS diet; overall chow intake in kcals did not differ on PSD1 and decreased on PSD2 (n group = 17, RM Two-way ANOVA. Interaction stress x day F(1,32) = 7.41, p = 0.01. PSD1 F(1,32) = 0.84, p = 0.37. PSD2 F(1,32) = 10.34, p = 0.003). e Ad libitum HFHS diet; Total caloric intake in kcals increased on PSD1 post stress (n group = 17, Two-way RM ANOVA. Main effect stress F(1,32) = 13.76, p = 0.0008; PSD1 F(1,32) = 15.64, p = 0.0004; PSD2 F(1,32) = 0.52, p = 0.47). f Ad libitum HFHS diet; palatable fat and sugar intake as a percentage from total caloric intake increased on PSD2 (n group = 17, RM Two-way ANOVA. Interaction stress x day F(1,32) = 5.40, p = 0.03; PSD1 F(1,32) = 2.08, p = 0.16; PSD2 F(1,32) = 23.26, p = 0.00003). g Limited access paradigm; Caloric intake from fat during 2 h on PSD1 and 2 increased. (n group = 10, RM Two-way ANOVA. Main effect stress F(1,18) = 7.071, p = 0.016; PSD1 F(1,18) = 2.80, p = 0.11; PSD2 F(1,18) = 7.33, p = 0.014). h Limited access paradigm; Caloric intake from chow after the 2 h fat exposure on PSD1 and 2 did not differ post stress (n group = 10, RM Two-way ANOVA. Main effect stress F(1,18) = 3.15, p = 0.09). i Limited access paradigm; Total caloric intake on PSD1 and 2 increased after stress (n group = 10, RM Two-way ANOVA. Main effect stress F(1,18) = 12.18, p = 0.0026; PSD1 F(1,18) = 7.75, p = 0.012; PSD2 F(1,18) = 7.84, p = 0.011). All data are shown as mean + SEM and statistical tests were performed two-sided. *p < 0.05; **p < 0.01; ***p < 0.001. Source data are provided as a Source Data file.

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