Fig. 2: Humoral immune responses against multiple antigens. | Nature Communications

Fig. 2: Humoral immune responses against multiple antigens.

From: A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain

Fig. 2

a Anti-spike (S), Nucleocapsid (NP), Envelope (E), and S-Omicron (S-O) antibodies were measured by ELISA at 2 weeks after the 3rd dose (3rd 2 wks), 26 weeks after the 3rd dose (3rd 26wks) or 2 weeks after the 4th dose (4th 2wks). b–d Antibody titers for each protein were compared between 3rd 2 wks and 26 wks (b), 4th 2 wks and 3rd 26 wks (c), 4th 2 wks and 3rd 2 wks (d), respectively. Percentage of participants with increased titers (former/later >1, orange), decreased titers (former/later <1, blue) or unchanged titers (former/later =1, green) were summarized. e Anti-S (blue circle) and anti-NP (orange triangle) antibody titers were compared between each time point. f Anti-E antibody titers at each time point were compared. g Antibody titers for S-Omicron. For (e–g), n = 38 biologically independent samples. Data were shown as Geometric mean ± 95% Cl. Two-tailed Friedman test followed by Dunn’s multiple comparisons test was used for (e–f). Source data are provided as a Source Data file.

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