Fig. 3: ADCC and T cell responses against multiple antigens. | Nature Communications

Fig. 3: ADCC and T cell responses against multiple antigens.

From: A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain

Fig. 3

a ADCC fold induction (FI) of each sample against unimmunized control was summarized. The dashed line indicates the threshold, sample/unimmunized = 1. Convalescent patients who had recovered from WT SARSCoV-2 infection were recruited as the positive control2. b The two-tailed spearman correlation coefficient was calculated on ADCC activities against WT and Omicron at 4th 2 wks. c–e T cell responses after the 3rd and 4th dose were measured by ELISPOT. Controls and representative spots from volunteer 56 were shown in (c), while S-specific or NP-specific T cell responses were summarized in (d) and (e), respectively. Pep, peptide pool. s.f.u., spot-forming units. For (a, b, d, e), n = 38 biologically independent samples, except for the convalescent patient group in which n = 5 biologically independent samples. Data were shown as box and whiskers, indicating median (middle line), 25th, 75th percentile (box) and 5th and 95th percentile (whiskers). Two-tailed Wilcoxon matched-pairs signed rank test was used for (d, e). Source data are provided as a Source Data file.

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