Fig. 4: The 4th dose did not further elevate the peak level of RBD-Nabs. | Nature Communications

Fig. 4: The 4th dose did not further elevate the peak level of RBD-Nabs.

From: A fourth dose of the inactivated SARS-CoV-2 vaccine redistributes humoral immunity to the N-terminal domain

Fig. 4

a NAbs to RBD (RBD-NAbs) were measured by a one-step competitive Chemiluminescent immunoassay for sera collected at various time points after 1st, 2nd, 3rd, and 4th doses. The kinetic of RBD-NAbs was shown for each participant. AU, arbitrary units. b Peak values of RBD-NAbs after each vaccination were compared. c Percentage of participants with increased peak value (increased >20%, orange), decreased value (decreased >20%, blue), or unchanged (±20%, green) as compared to the previous peak were summarized. d The two-tailed spearman correlation coefficient was calculated for the peak value after the 3rd dose and the fold change of peak value from the 3rd to the 4th dose in the decreased group shown in (c). e Kinetics of RBD-NAbs were compared among various time points after the 3rd and 4th dose. For (b, e), n = 38 biologically independent samples. Data were shown as Geometric mean ± 95% Cl. RM one-way ANOVA followed by Bonferroni’s multiple comparisons test was used for (b). Source data are provided as a Source Data file.

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