Fig. 2: Fitting a kinetic model to the stimulus-response data.
From: Kinetics of mRNA nuclear export regulate innate immune response gene expression
A Model linking mRNA measurements in different subcellular fractions, with associated equations. B Schematic of the fitting workflow that takes the expression of caRNA as input, simulates the nucleoplasmic and cytoplasmic mRNA abundances, and iterates to identify the optimal parameter set for each gene. C Heatmap of fitting results alongside the data. Most genes fit the data really well, as indicated in the Fit Quality bar on the left-hand side. Source data are provided as a Source Data file. D Example of fitting results for Egr1 and Malt1 genes for the three replicates. The error bars represent the 95% prediction interval of the model given the data library size.
