Fig. 4: Export rates vary widely across immune response genes.
From: Kinetics of mRNA nuclear export regulate innate immune response gene expression
A Left panel shows the histogram of nucleoplasmic export efficiencies (k2’/k2) for immune response genes. The distributions are similar for the different replicates and span a 30-fold difference between genes. Middle panel shows the reproducibility of these export efficiency estimates. Right panel shows the number of genes for which this quantity is identifiable. B Left panel shows the histogram of effective transport rates (k1’k2’/k2) for immune response genes. The distributions are similar for the different replicates and span a 100-fold difference between genes. Middle panel shows the reproducibility of these effective transport rate estimates. Right panel shows the number of genes for which this quantity is identifiable. C Correlation of the nucleoplasmic export efficiency and the effective transport rate for the genes for which both parameters are identifiable. D The distributions of effective transport rates of genes involved in various biological processes. E Example expression for two genes having effective transport rates (k1’k2’/k2) on the extremes of the distribution. Malt1 has a low effective transport rate and Egr1 has a high rate. From the line graph (top), we noticed that even though Egr1 is less expressed than Malt1 in the chromatin fraction, its expression ends up being higher in the cytoplasmic fraction.
