Fig. 3: β-sheet structure in the vascular and in the glomerular fibril.
From: Amyloid fibril structure from the vascular variant of systemic AA amyloidosis
a Sequence of SAA1.1 shown side by side with schematic representations of the fibril proteins from the vascular (stacks A and B) and glomerular fibril. Continuous gray lines: fibril core segment; dotted lines: disordered segments; arrows: β-strands. b Ribbon diagram of one molecular layer of the vascular fibril. β-strands are labeled with β1 to β8. c Ribbon diagram of residues 2–10 of the glomerular and vascular fibril (stacks A and B) showing the different twists of sheet β1. Only every third molecule along the fibril axis is shown. d Side views of the 3D maps of the vascular (left) and glomerular fibril (right). e Ramachandran plot of the residues in the β-sheets of the vascular and glomerular fibril. The data for the glomerular fibrils were plotted based on the PDB entry 6MST [https://www.rcsb.org/structure/6MST]13. The color coding is consistent in all panels, as explained in panel e. Source data are provided as a Source Data file.
