Fig. 4: Detail structural features of the vascular and glomerular fibril.
From: Amyloid fibril structure from the vascular variant of systemic AA amyloidosis
a Ribbon diagrams of residues Ala27-Asp33 which are close to the fibril axis, in the vascular and glomerular fibrils, showing the staggered arrangement of the two fibril protein stacks. The fibril proteins are labeled with i − 4 to i + 7. b Ribbon diagrams of residues Ser2-Ala20 from the N-terminal arch, indicating the flipped positions of Phe6 and Trp18. c Comparison of the fibril proteins in the glomerular and vascular fibrils showing the different relative positions of the fibril protein N-terminus. Top: layers i; bottom: layers i + 1. The arrow is drawn to emphasize the different positions of the fibril protein N-terminus. Tyr29 (red) serves as a reference point.
