Fig. 5: Hydroalkenylation of internal alkenes with alkenyl boronic acids. | Nature Communications

Fig. 5: Hydroalkenylation of internal alkenes with alkenyl boronic acids.

From: Ligand-enabled Ni-catalyzed hydroarylation and hydroalkenylation of internal alkenes with organoborons

Fig. 5

The values under each structure indicate isolated yields. The regioselectivity was determined by analysis of the crude 1H NMR (rr > 99/1 for all substrates). Reaction conditions: 4 (0.2 mmol, 1.0 equiv), 6 (0.6 mmol, 3.0 equiv), Ni(OTf)2 (10 mol%), L14 (10 mol%), Na3PO4 (0.6 mmol, 3.0 equiv), t-AmylOH (1.0 mL), 80 °C, N2, 24 h. The Z/E mixtures were used for most of substrates. For 7a and 7d, (E)-1 and (E)-4k were used; For 7g–j, (Z)-4s was used.

Back to article page