Fig. 5: Cheetah and cat AA amyloid are 99% identical. | Nature Communications

Fig. 5: Cheetah and cat AA amyloid are 99% identical.

From: Cryo-EM structure of ex vivo fibrils associated with extreme AA amyloidosis prevalence in a cat shelter

Fig. 5

Sequence alignment of extracted cat and cheetah amyloid (Q1T770 and B0M1H2) identified in this and a previous study39. Sequence conservation is based on a multiple sequence alignment90,92 comprising ten cat and cheetah SAA variants (A0A2I2UCY9, A0A6J2AHC5, A0A337S9A8, A0A337SUS3, A0A6J2AJW0, M3WHE0, A0A5F5XYT5, A0A337SKP2). Single-residue substitutions are highlighted on sequence (left) and structure level (right). Substitution tolerance was estimated based on simple structural considerations, and colored in green (tolerated), yellow (tolerated with adjustments) and red (not tolerated). Cat AA amyloid is shown as gray cartoon. Large and small spheres highlight the positions of single-residue substitutions in fibrils and other SAA variants, respectively.

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