Fig. 7: End-to-end SNR simulation of insulin sensor.
From: Pre-equilibrium biosensors as an approach towards rapid and continuous molecular measurements
a A trapezoidal test concentration signal with T0 = 100 pM, T1 = 50 pM, and a period of 10 min (1/600 Hz). b We simulated the response of three receptors with constant KD = 500 pM but decreasing kinetics, where ΩT/ΩC = 0.1, 1, or 10. Also shown for comparison is the noise N[n] introduced by the detector system (black dots). N[n] is zero-mean white noise with a standard deviation of 0.005 fraction bound. c The receptor response was sampled with fS = 1/15 Hz, combined with N[n], and then filtered to remove all frequency content >fT. Because we aimed to resolve four harmonics above the fundamental, we choose \({f}_{T}=4/600\) Hz. d Estimated target concentration, E[n], at the output of the TEA. e Simulations for systems with KD = 500 pM over a range of \({\Omega }_{T}/{\Omega }_{C}\), where output noise and SNR were measured. Each simulation scenario is also reported in terms of the corresponding kon and koff values. Dotted lines depict Eq. 13 and Eq. 14.
