Fig. 7: Model depicting how PCGF1-PRC1 contributes to regulate early hematopoiesis. | Nature Communications

Fig. 7: Model depicting how PCGF1-PRC1 contributes to regulate early hematopoiesis.

From: PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment

Fig. 7

Two distinct PRC1 pathways, replication-related and H2AK119ub1-dependent pathways, are cooperatively used to facilitate early hematopoiesis as shown in the right panel. PCGF1-PRC1 prevents excess accession of chromatin remodeling factors, such as BRG1, to the nascent DNA in replication-associated manner and, in turn, facilitate H3K27me3 deposition by PRC2 via maintenance of proper nucleosome density. Other variant PRC1 incorporating PCGF3/5/6 are expected to facilitate PRC2 loading via H2AK119ub1-dependent manner. PCGF1-PRC1 contributes to maintain proper identities of HSPCs by inhibiting the inappropriate emergence of TMPs as depicted in the left panel.

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