Fig. 6: ARG content of diarrheagenic E. coli isolates.
From: Impact of international travel and diarrhea on gut microbiome and resistome dynamics
a Boxplot shows higher number of unique ARGs carried by DEC strains in non-diarrhea samples of TD subjects compared to HT subjects (n = 189, Wilcoxon test, P < 0.05). The colored data points represent different DEC strain. P values are multiple-hypothesis test corrected using Benjamini–Hochberg (FDR) method. Boxes show median and quartiles; error bars extend to the values within 1.5 interquartile range. Dotplot at the bottom shows the prevalence of ARGs in DEC isolates obtained from non-diarrheal HT and non-diarrheal TD subjects’ samples. The annotated genes (blaTEM-148, sul2, aph6, and tetA) were significantly associated with TD subjects after FDR correction (Fisher exact test; P < 0.05). b Co-occurrence network of ARGs (circles) and mobile elements (triangles). The edges between two nodes represents the correlation of ARGs and mobile elements in the same contig (within 5 kb). Solid lines represent significant relationships after FDR correction (Student’s t test, P < 0.05) and shaded regions represent subnetworks. c Examples of arrangements of ARGs and mobile elements identified on the same contigs. Underlying data are provided in the Source Data file.
