Fig. 4: Schematic illustrating effects of STL1267 binding and comparison to apo REV-ERBα and heme bound REV-ERBβ.
From: Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB
a Overlay of the REV-ERBα/NCoR ID1/STL1267 (protein is shown as green ribbons, NCoR peptide as blue ribbons and ligand carbons are shown in purple) and REV-ERBα/NCoR ID1 (protein is shown as orange ribbons, NCoR peptide as pink ribbons, PDB:3N00). b Detailed view of the superimposed ligand binding pockets of both structures. Orange amino acid residues corresponds to the apo REV-ERBα, green amino acid residues correspond to the STL1267/REV-ERBα. The ligand is illustrated by purple carbons. c Overlay of the REV-ERBα/STL1267 (purple) and REV-ERBβ/heme (yellow). d Detailed view of STL1267 within the REV-ERBα LBD. Ligand is colored gray. e Detailed view of heme within the REV-ERBβ LBD (heme is colored gray and the orange sphere represents iron).
