Fig. 5: Distinct conformations of NCoR1 ID1 peptide binding to REV-ERB induced by STL1267 vs heme.
From: Structural basis of synthetic agonist activation of the nuclear receptor REV-ERB
a Structure of STL1267/REV-ERBα LBD (yellow) bound to NCoR1 ID1 peptide (purple). Regions of the receptor interacting with NCoR are represented in gray. STL1267 is represented in space filled format. b Structure of heme/REV-ERBβ LBD (yellow) bound to NCoR1 ID1 peptide (purple) (PDB: 6WMQ). Regions of the receptor interacting with NCoR are represented in gray. Heme is represented in space filled format.
