Fig. 2: FoxH1-GK complexes structure.
From: Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1
a Zebrafish and human FoxH1-GG complexes. The K+ cation is displayed as a violet sphere. The GG sequence and the elements of secondary structure are indicated. Wing1 and 2 are colored in blue. b Schematic drawing of the secondary structure elements. The core domain is shown in beige and the novel Wing2 in blue. c Superposition of the human, frog and zebrafish FoxH1-GG complexes. Regions with differences between structures are indicated as arrows. d Superposition of the zebrafish FoxH1-GG and GT complexes. e Specific contacts for the zebrafish complex refined at 0.98 Å resolution showing how FoxH1 recognizes a DNA segment of 15 bp through a rich network of direct contacts involving the major groove and both adjacent minor grooves. Residues are color coded as in panel (a).
