Fig. 7: Polymerase uncoupling at common fragile sites FR3B and FRA16D.
From: Global landscape of replicative DNA polymerase usage in the human genome
a Correlation of coupling index of rightward and leftward moving forks presented by chromosome. Chromosomes 1, 3 and 16 are shown. The dashed circles highlight data points dispersed from the bulk of population. These outlier data points were identified by Smirnov-Grubbs test. r represents Pearson correlation coefficient and p shows its statistical significance (one-tailed t-test). b Top: profiles of coupling index for rightward and leftward forks. Middle: fork index profile. Bottom: mean replication timing (mean RT) or DSB data for the FRA3B region on chromosome 3. Grey bars mask regions where the profiles are void due to a low count of sequencing reads (see methods). c The equivalent data for the FRA16D region of chromosome 16. Replication timing data for HCT116 cells are derived from Zao et al. 24. Data of DSBs from End-seq are derived from Tubbs et al. 35.
