Fig. 1: SARS-CoV-2 antibody responses at Day 36 post-infection in children infected with Wuhan (black), Delta (blue), or Omicron (red) variant and children previously vaccinated and then infected with Omicron (orange).
From: Comparison of antibody responses to SARS-CoV-2 variants in Australian children
a SARS-CoV-2 Immunoglobulin G (IgG) Seropositivity Rate measured by IgG ELISA using the Wuhan S1 antigen and compared using Fisher’s Exact test. b SARS-CoV-2 IgG concentrations as measured by ELISA using the Wuhan S1 antigen. c SARS-CoV-2 neutralizing antibodies as measured by surrogate virus neutralization test using the Wuhan-specific RBD antigen. Comparison of S1-specific IgG antibody concentrations and neutralizing antibodies (% inhibition) between children from different SARS-CoV-2 waves, between unvaccinated and vaccinated were done using a two-sided Mann–Whitney U test. d SARS-CoV-2 neutralizing antibodies as measured by surrogate virus neutralization test using Wuhan RBD- or Omicron RBD-specific antigen; variant-specific antibody responses were compared using a two sided Wilcoxon-signed rank test. Dotted lines indicate seropositivity cut-off. Each data point represents a seropositive individual participant for each wave (Wuhan, n = 21; Delta, n = 35; Omicron, n = 13) and for those vaccinated and then infected (n = 24). Data presented as geometric mean concentrations ± 95% confidence intervals. BAU, binding antibody units. Source data are provided as a Source Data file.
