Fig. 3: Creb5 is necessary for the formation of many synovial joints.
From: Creb5 coordinates synovial joint formation with the genesis of articular cartilage
a Alcian Blue/Alizarin Red staining of the knees and autopods of P0 Creb5Δ9/Δ9 mice or their WT littermates. Gene expression assayed by FISH and immunocytochemistry for Creb5 and carboxy-terminal phosphorylated Smad2 (pSmad2) in sections of the knees (b) and elbows (c) of P0 Creb5Δ9/Δ9 mice or their control littermates. Parallel sections were stained with Safranin O/Fast Green (FG). Femur (F), Tibia (T), Humerus (H) and Radius (R) are indicated. Similar results were obtained in either 14 (a), 4 (b) or 2 (c) independent biological repeats. Scale bar equals 200 microns.
