Fig. 5: Fluxome-wide association analysis (FWAS) between genetically personalised flux values and coronary artery disease.
From: Genetically personalised organ-specific metabolic models in health and disease
a quantile-quantile (QQ) plot of the observed P values for associations between flux values and coronary artery disease risk. The red line indicates the expected distribution of P values under a uniform distribution (i.e., null hypothesis) and the area coloured in grey shows the 95% confidence intervals of such distribution. b Plot of the statistically significant (FDR-adjusted P value < 0.05) flux hazard ratios per organ on coronary artery disease risk. The violin plot, coloured in pale azure, shows the distribution of both significant and non-significant hazard ratios. Statistical significance of the association of each flux to coronary artery disease was evaluated with a Cox proportional hazards regression (two-tailed Wald test for flux hazard ratios; Methods).
