Table 1 Top associations between metabolic fluxes and lipoproteins in the hepatic triacylglycerol to cholesteryl ester pathway
From: Genetically personalised organ-specific metabolic models in health and disease
Reaction | Blood metabolic feature | Effect size | FDR-adjusted P value (INTERVAL) | FDR-adjusted P value (UKB) |
|---|---|---|---|---|
Triacylglycerol lipase | HDL_CE_pct | + | 3.48 × 10−31 | 2.22 × 10−72 |
HDL_CE_pct_C | + | 1.86 × 10−73 | <2.225 × 10−308 | |
HDL_size | − | 2.97 × 10−50 | 4.67 × 10−292 | |
HDL_TG | − | 9.88 × 10−74 | 1.12 × 10−245 | |
LDL_TG | − | 3.37 × 10−78 | 3.30 × 10−250 | |
Ethanolamine phosphotransferase | HDL_CE_pct | + | 1.49 × 10−29 | 5.98 × 10−70 |
HDL_CE_pct_C | + | 4.39 × 10−74 | <2.225 × 10−308 | |
HDL_size | − | 4.25 × 10−53 | 9.52 × 10−307 | |
HDL_TG | − | 2.86 × 10−73 | 1.60 × 10−249 | |
LDL_TG | − | 3.99 × 10−79 | 1.97 × 10−259 | |
Lecithin-cholesterol acyltransferase | HDL_CE_pct | + | 5.45 × 10−22 | 1.15 × 10−52 |
HDL_CE_pct_C | + | 4.60 × 10−46 | 1.12 × 10−235 | |
HDL_size | − | 4.24 × 10−33 | 2.17 × 10−206 | |
HDL_TG | − | 7.02 × 10−54 | 3.70 × 10−171 | |
LDL_TG | − | 9.03 × 10−55 | 2.05 × 10−171 | |
Cholesteryl ester release | HDL_CE_pct | + | 3.76 × 10−26 | 4.17 × 10−62 |
HDL_CE_pct_C | + | 5.19 × 10−59 | 8.75 × 10−291 | |
HDL_size | − | 2.17 × 10−41 | 8.02 × 10−254 | |
HDL_TG | − | 1.97 × 10−61 | 8.76 × 10−206 | |
LDL_TG | − | 1.23 × 10−66 | 1.35 × 10−215 | |
Cholesterol esterase | HDL_CE_pct | − | 1.50 × 10−23 | 4.31 × 10−57 |
HDL_CE_pct_C | − | 4.32 × 10−60 | 2.10 × 10−264 | |
HDL_size | + | 5.11 × 10−37 | 1.29 × 10−226 | |
HDL_TG | + | 3.90 × 10−51 | 7.37 × 10−186 | |
LDL_TG | + | 2.92 × 10−60 | 2.56 × 10−200 | |
Retinyl ester hydrolase | HDL_CE_pct | − | 3.76 × 10−23 | 1.04 × 10−53 |
HDL_CE_pct_C | − | 8.90 × 10−57 | 1.24 × 10−261 | |
HDL_size | + | 2.15 × 10−37 | 1.87 × 10−227 | |
HDL_TG | + | 3.14 × 10−49 | 1.54 × 10−175 | |
LDL_TG | + | 2.19 × 10−57 | 3.34 × 10−193 |
