Fig. 2: Overlap between genomic positions identified by corresponding GWAS and EWAS.
From: A comparison of the genes and genesets identified by GWAS and EWAS of fifteen complex traits
The genome was divided into 500kb regions. Those where no probes on the HM450 array measured DNAm were excluded from the analysis. This left 5591 regions. Regions were counted as being identified by a GWAS if one or more SNPs in that region associated with the trait and as being identified by an EWAS if one or more CpGs in that region associated with the trait. Neither = no GWAS or EWAS sites identified in the region, GWAS = GWAS sites only were identified, EWAS = EWAS sites only were identified, Both = Both GWAS and EWAS sites were identified, AC alcohol consumption per day, BW birthweight, BMI body mass index, Cog cognitive ability (digit test), CRP c-reactive protein, CsNs current smokers vs never smokers, DBP diastolic blood pressure, EA educational attainment, Gluc fasting glucose, Ins fasting insulin, FEV1 forced expiratory volume in one second, FsNs former smokers vs never smokers, SBP systolic blood pressure.
