Fig. 5: Reaction mechanism investigation. | Nature Communications

Fig. 5: Reaction mechanism investigation.

From: Chiral aldehyde-nickel dual catalysis enables asymmetric α−propargylation of amino acids and stereodivergent synthesis of NP25302

Fig. 5

a Control experiments with modified chiral aldehyde catalysts. b Control experiments to investigate the role of nickel and ZnCl2. c Control experiments with Schiff base as reactants. d The nonlinear effect investigation between the ee value of product 4a and chiral sources 3i or L1. e The possible catalytic cycles. (x = the equivalents of Ni(COD)2, y = the equivalents of ZnCl2).

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