Fig. 2: Comparative proteome analysis of different macrophage populations revealed the involvement of macrophages in the regulation of the function of resident tissues.
From: Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
a Heatmap of Pearson correlation analysis results for different modules defined by carrying out WGCNA. b Protein expression profiles and representative signatures or hub genes of CTMs across different macrophage populations. Each line represents one protein. The average profile is shown in black. c Macrophage module network. Edges represent Pearson correlation coefficients coded by gradually varied color and thickness. Module size is represented by node size and the characteristics of each module are noted (one-sided Fisher’s exact test, p < 0.05). d Network depicting the diverse PRR proteins in different macrophages. Edges represent weighted correlations (weight) shown with gradually varied colors. Only network connections whose weighted correlations are above the threshold of 0.10 are shown. e Proteomic quantifications of TLRs across the 12 macrophage populations. The expression values are log10-transformed copy numbers per cell. The gray blocks with a cross represent missing values. f Bar plots of Tlr4/Tlr5 expression across the 12 macrophage populations. n = 3 biologically independent experiments (Data are presented as mean ± SD). Source data are provided as a Source Data file.
