Fig. 3: Macrophage proteome pattern revealed a TF regulatory network and hierarchical crosstalk between macrophages and relevant tissues.
From: Integrated proteomic and transcriptomic landscape of macrophages in mouse tissues
a The numbers of cell-type-specific TFs and their fractions among the total identified TFs in different macrophage populations. b Expression pattern and regulatory network of ctmTFs with high gene significant values in CTMs. Values for each protein (ranked along with genes from top left to bottom right in the relevant network) expression across all populations are color-coded based on z-scored copy numbers per cell in the heatmap. The red nodes indicate ctmTFs and the blue nodes indicate relevant TGs in the network. c Profiles of the H3K4me1 signal in 35 kb regions with ATAC-seq peaks (shown in black) overlaid on the profiles, with enhancers around the indicated proteins contained. Shaded regions indicate the locations of the relevant motifs. The bar plots depict the protein expression levels of Pparg and Abcg1 in the alveolar macrophages, and of Elf3 and St14 in the large intestinal macrophages. Source data are provided as a Source Data file.
