Fig. 1: MSI1 is overexpressed in G3 MB. | Nature Communications

Fig. 1: MSI1 is overexpressed in G3 MB.

From: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

Fig. 1

a Tumor burden analysis of mice orthotopically transplanted with Cre-infected Msi1flox/flox showing no luminescence in Cre mediated Msi1 KO MP tumors indicating impaired tumor formation compared to GFP control mice, b Kaplan-Meier survival analysis of Cre-mediated Msi1 KO mice (n = 10), control GFP mice (n = 10) and untransduced MP mice (n = 7) illustrating a clear survival benefit for the Cre-mediated Msi1 KO cohort (p < 0.001), c 24 NOD-SCID mice were engrafted with SU_MB002 with 2.5 × 104 cells. H&E stain of control vs shMSI1 KD SU_MB002 transplanted mice in the tumor burden arm demonstrating large tumors in the control vs shMSI1 harvested brains (bars represent 100 μm), d Kaplan–Meier survival curve of control vs shMSI1 KD SU_MB002 transplanted mice (p < 0.0008), e Pathways analysis of differentially MSI1 eCLIP bound transcripts identifying key processes that are aberrant in SU_MB002 as compared to NSC201cb (>2logFC).

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