Fig. 4: Robust ranked analysis (RRA) identifies TMEM33, SFNX3 and HIPK1 gene set directly perturbed by MSI1 in G3 MB. | Nature Communications

Fig. 4: Robust ranked analysis (RRA) identifies TMEM33, SFNX3 and HIPK1 gene set directly perturbed by MSI1 in G3 MB.

From: Characterization of an RNA binding protein interactome reveals a context-specific post-transcriptional landscape of MYC-amplified medulloblastoma

Fig. 4

a Pathways analysis illustrating the main pathways perturbed by the binding of MSI1 to its target (Purple:eCLIP, Green:RNA-seq, Yellow:polysome-seq, Blue: proteomics (TMT-MS), Pink: RRA). The associated heat map shows the RRA rank and gene association (Yellow denotes non-significant association) with a cancer annotated gene (fuchsia) or MB associated gene (salmon), b TMEM33, SFNX3 and HIPK1 changes after shMSI1 inhibition in G3 MB), c Circos plot showing significantly perturbed genes after shMSI1 inhibition and their regulation by MYC (Reactome Functional Interaction).

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