Fig. 5: Differential gene expression in human neural cells triggered by metformin and glyburide: markedly reduced levels of the AD biomarker SPP1 (osteopontin). | Nature Communications

Fig. 5: Differential gene expression in human neural cells triggered by metformin and glyburide: markedly reduced levels of the AD biomarker SPP1 (osteopontin).

From: Causal inference in medical records and complementary systems pharmacology for metformin drug repurposing towards dementia

Fig. 5

a Differentiated human ReN VM cells into neural cells were treated with metformin or glyburide at two different concentrations, for either 24 or 72 h. b Genes with largest dose-dependent change in expression over 24 and 72 h, for either metformin or glyburide—top 4 increased and top 4 decreased. c Genes expressing secreted proteins with greatest differential between metformin and glyburide. d SPP1 RNA levels in 4 different brain regions: AD vs. Controls. DLPFC dorsolateral prefrontal cortex, PHG parahippocampal gyrus, STS superior temporal sulcus, TC temporal cortex.

Back to article page