Fig. 2: Distinct cell compositions of HC, DLE, and SLE.
From: Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
a, b Bar plots show the proportions of 6 cell types in the epidermis (a) and 8 cell types in the dermis (b) of biopsy samples from DLE and SLE patients. Macro/DC: macrophages/dendritic cell. c Histogram plots comparing the proportions of the main immune cell types, including T cells, B cells, Macro/DCs and NK cells in dermis of HCs (n = 4), DLE patients (n = 5), and SLE patients (n = 7). The histograms for HCs are shown in pink, histograms for DLE are in red and histograms for SLE are in blue. Data were presented as mean ± SD, the P values were calculated using a one-way ANOVA test with Bonferroni’s multiple comparisons test. *P < 0.05, **P < 0.01, ***P < 0.001, ns: no significance. T cells: DLE vs HC, P = 0.0002; SLE vs DLE, P = 0.0004, B cells: DLE vs HC, P = 0.0036; SLE vs DLE, P = 0.0027. NK cells: DLE vs HC, P = 0.0099; SLE vs DLE, P = 0.0090. d Represent images show immunofluorescence staining for CD3 (green)/CD19 (red) for T cells/B cells, CD56 (green) for NK cells in HCs, DLE and SLE samples. The dotted line outlines the dermal-epidermal junction. Parts of the stained area were enlarged in the corresponding single-unit grid. Scale bar: 100 µM. Data are representative of three independent experiments. Source data are provided as a Source Data file.
