Fig. 9: Cell-cell interaction in epidermis and dermis.
From: Single-cell sequencing shows cellular heterogeneity of cutaneous lesions in lupus erythematosus
a, b Heatmaps show interaction scores between cell types in epidermis (a) and dermis (b). The column annotation represents cells from HC/DLE/SLE. The purple color shows the low interaction scores, while the red color shows high interaction scores. c, d Bubble diagrams show the mean expression levels of selected ligand-receptor pairs in epidermal (c) or dermal (d) cell types of HC/DLE/SLE. The P values were calculated using one-side permutation test. e Represent images show immunofluorescence staining for CCL19 (green) expression in fibroblasts (Vimentin, red), CCR7 (green) expression in macrophages (CD68, red). Scale bar: 100 µM. Data are representative of 3 independent experiments. Macro/DC: macrophage/dendritic cell. Source data are provided as a Source Data file.
