Fig. 1: The expanded VTD family.

a Structure-guided alignment of representative members. Residues printed on black or grey background are invariant or conservatively replaced in at least 50% of the sequences. The active site residues are highlighted in red, the loop associated with K6-specificity is shown in blue. b Domain architecture of the proteins analyzed in this work. Active and inactive VTD domains are shown in blue, other DUB-domains in green, transmembrane-regions in orange and other domain types in grey. The position of the VDT domains as aligned in part a) of the figure are indicated by numbers.