Fig. 4: Endoscopic imaging of a rat rectum for visualization of the hemodynamic response during acute inflammation.

a Time-lapse images acquired by the photoacoustic endoscope over 90 min. The hemoglobin concentration (CHb), depth, and oxygen saturation (sO2) images are presented. The white boxes represent the same imaging region of interest for the statistics. b Oxygen saturation distribution changes with respect to the baseline at 30 min intervals. Blue: baseline; red: result from each time-lapse image. c Time-dependent changes in the hemoglobin concentration, oxygen saturation and vessel density. Data are presented as the mean±standard deviation, n = 3 biologically independent rats were used, one-way repeated-measures analysis of variance (ANOVA and Dunnett’s T3 multiple comparisons test) was used in here. *p < 0.05. Scale bar: 0.5 mm.