Fig. 1: Identification and annotation of kidney parenchymal cells. | Nature Communications

Fig. 1: Identification and annotation of kidney parenchymal cells.

From: Single-cell profiling of healthy human kidney reveals features of sex-based transcriptional programs and tissue-specific immunity

Fig. 1

a Different cell type proportions were captured by sequencing total kidney homogenate and CD45-enriched samples to create the total combined dataset. b UMAP clustering of total combined dataset with cell type annotations. c Graphical depiction of location of nephron cell types captured within the data. d UMAP plot of compartment-specific analysis of 20772 proximal tubular cells, comprising 6 clusters. e Heat map showing the expression levels of cluster marker genes. f UMAP plot of compartment-specific analysis of 4436 non-proximal tubular parenchymal cells, with 14 cell populations represented, including four distinct endothelial clusters. g Heat map showing the expression levels of cell type marker genes across the 14 non-PT cell populations. PT Proximal tubule, DCT Distal convoluted tubule, CNT Connecting tubule, LOH Loop of Henle, cTAL Cortical thick ascending limb, CCD Cortical collecting duct, PC Principal cell, IC Intercalated cell, Mes Mesangial, Podo Podocyte, Endo Endothelial, PEC Parietal epithelial cell, NK Natural Killer, MNP Mononuclear phagocyte.

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