Fig. 7: Nr6a1 and Gdf11 signalling cooperate in the control of Hox cluster transitions.
From: Nr6a1 controls Hox expression dynamics and is a master regulator of vertebrate trunk development
A, B Differential Hox expression kinetics observed during in vitro differentiation of Nr6a1 and wildtype ESCs. Source data are provided as a Source Data file. A RNAseq analysis of trunk Hox gene expression (Hox6-9) in Nr6a1−/− (red) and wildtype (blue) cells. In vitro differentiation protocol schematised, analysis timepoints marked with asterisk and data represented as counts per million (CPM). Only those genes showing a false discovery rate (FDR) < 0.05 are visualised. B RNAseq analysis of posterior Hox gene expression (Hox10-13) in Nr6a1−/− (red) and wildtype (blue) cells. In vitro differentiation protocol schematised, analysis timepoints marked with asterisk and data represented as counts per million (CPM). Only those genes showing a false discovery rate (FDR) < 0.05 are visualised. G = addition of Gdf11.
