Fig. 1: Schematic demonstrating traditional and data-driven formulation development approaches for long-acting injectables (LAIs).
From: Machine learning models to accelerate the design of polymeric long-acting injectables
a Selected routes of administration for FDA-approved LAI formulations. b Typical trial-and-error loop commonly employed during the development of LAIs termed “traditional LAI formulation development”. c Workflow employed in this study to train and analyze machine learning (ML) models to accelerate the design of new LAI systems, termed “Data-driven LAI formulation development”.
