Fig. 9: USP18 loss-induced atypical ISG PLK2 regulates leukemogenesis.
From: Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
a Survival of sub-lethally irradiated recipient mice transplanted (i.v.) with Plk2 doxycycline inducible C1498 or AE9a cells (C1498, n = 5 mice each, AE9a, n = 8 mice each). Two weeks after transplantation, mice were fed with or without doxycycline water (400 μg/ml, 5 % sucrose). p-value was determined by two-tailed Gehan–Breslow–Wilcoxon test (for C1498) or log-rank test (for AE9a). PLK2 induction in C1498 cells are also shown. b Survival for recipients of SgCtrl or SgPlk2 infected Usp18+/f or +/Δ UBCER-Cre AE9a-GFP AMLs. p-value between +/f SgCtrl and +/Δ SgPLK2, and +/Δ SgCtrl and +/Δ SgPLK2 were determined by log-rank test. (right, n = 7 mice each group). Western blot of PLK2 protein level in SgRNAs expressing cells (left). c Analysis of GFP % of (m) in PB. p-value was determined by one-way ANOVA test. d Model of USP18-STAT2 mediated ISGs regulation followed by pyroptosis. Source data are provided as a Source Data file.
