Fig. 8: Previously published and newly proposed syntheses of arformoterol.
From: Merging enzymatic and synthetic chemistry with computational synthesis planning
a–c Overview of published syntheses of arformoterol. d Proposed hybrid synthesis plan. Enzyme names were assigned to steps based on the most structurally similar precedent reaction for reference. Arformoterol does not appear in the training set of the model. AMO alkene monooxygenase, F5H ferulate 5-hydroxylase, LAM lysine 5,6-aminomutase, CYP2D6 Cytochrome P450 2D6, COMT catechol O-methyltransferase.
