Table 1 Clinical and demographic characteristics of the adult and pediatric TB patients, and control individuals, either healthy or with bacterial pneumonia

From: A Mycobacterium tuberculosis fingerprint in human breath allows tuberculosis detection

 

Adult TB patients

 

Smear-positive

Smear-negative

  

Culture-negative

Culture-positive

Number of patients

8

7

14

Gender M/F

6/2

5/2

8/6

Age

 Median

34

44

38

 Minimal

27

19

21

 Maximal

62

70

68

TSTa (positive/performed)

7/8

5/7

8/14

TST diameter (mm)b

13 ± 2 (9–16)

11 ± 2 (3–14)

9 ± 5 (3–14)

BCG scar positive/total

6/8

6/7

10/14

Primary treatment

Isoniazid

Isoniazid

Isoniazid

 

Rifampicin

Rifampicin

Rifampicin

Time of EBC collection

Under antibiotic treatment for <2 week

Before antibiotic treatment

Under antibiotic treatment for <2 week

Label

Ad S+

Ad S-C-

Ad S-C+

 

Pediatric TB patients

 

String-test smear- or culture-positive

String-test smear- and culture-negative

Number of patients

5

12

Gender M/F

3/2

6/6

Age

 Median

9

9

 Minimal

6

6

 Maximal

12

12

TSTa (positive/performed)

3/5

11/12

TST diameter (mm)b

11 ± 5 (6–14)

9 ± 3 (4–16)

BCG scar (positive/total)

3/5

9/12

Primary treatment

Isoniazid

Isoniazid

 

Rifampicin

Rifampicin

Time of EBC collection

Before antibiotic treatment

Under antibiotic treatment for <2 week, and at months 1 and 3c

Label

Ch S+/C+

Ch S-C-

 

Control individuals

 

Community-acquired pneumonia

Healthy

 

Gram negative

Gram positive

Children

Adult

Number of persons

8

7

15

15

Gender M/F

4/4

4/3

10/5

12/3

Age

 Median

42

41

9

34

 Minimal

18

20

7

26

 Maximal

60

61

12

49

TSTa (positive/performed)

Unknown

Unknown

10/15

14/15

TST diameter (mm)b

Unknown

Unknown

0 ± 0.1 (0–0.3)

16 ± 5 (7–24)

BCG scar (positive/total)

Unknown

Unknown

10/15

14/15

Treatment

Moxifloxacin or Levofloxacin. Clindamycin

Moxifloxacin or Levofloxacin. Amikacin

N/A

N/A

Time of EBC collection

Before antibiotic treatment

Before antibiotic treatment

N/A

N/A

Label

Ad pneumo

Ch healthy

Ad healthy

  1. N/A not applicable.
  2. aTuberculin skin test.
  3. bMean ± SD (range).
  4. cSix (3M/3F; BCG scar positive; 6–12 years old) of the 12 patients were followed during antibiotic treatment and EBC collected after 1 and 3 months of antibiotic therapy.
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