Fig. 5: Dynamic temporal changes in circulating cytokines and receptors vary between severe and mild COVID-19. | Nature Communications

Fig. 5: Dynamic temporal changes in circulating cytokines and receptors vary between severe and mild COVID-19.

From: Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence

Fig. 5

a Heatmap displaying proteins with a significantly different temporal profile in mild vs severe disease (TxCC, LMM, FDR < 0.05). Colour indicates LMM estimated marginal means over time, stratified by patient group (n = 169 samples from 40 individuals). Proteins are clustered based on the temporal profile of the discordance between mild/moderate and severe/critical disease. Proteins are annotated using gene symbols, with alternative common protein identifiers in parentheses. b–e Examples of proteins with differing patterns of discordance over time in severe/critical versus mild/moderate patients (TxCC, LMM, FDR < 0.05). Lines represent estimated marginal means and shaded areas represent their 95% confidence intervals. The raw proteomic profiles display protein abundance for each individual (n = 169 samples from 40 individuals).

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