Fig. 6: Subtype-specific gene expression.
From: Molecular subtypes of ALS are associated with differences in patient prognosis
a Heatmap showing expression of 36 subtype-specific transcripts for all patient samples considered in this study. Count values are adjusted for RIN, site of sample preparation, and sequencing platform covariates. Expression is z-score normalized, using ALS patient expression to define the mean and standard deviation. Control samples with a z-score < –4 are adjusted to –4 for plotting purposes. b Presentation of FDR-adjusted p-values following pairwise differential expression analysis. P-values are –log10 transformed prior to plotting. Gray colored entries indicate an adjusted p-value > 0.05. P, DESeq214 differential expression using the negative binomial distribution, two-tailed, FDR method for multiple hypothesis test correction. Source data are provided as a Source Data file.
