Fig. 5: Conditional St18 KO produces a specific loss of MGE lineage GPe projection neurons.
From: St18 specifies globus pallidus projection neuron identity in MGE lineage
a Quantification of PV + neurons (Unpaired t-test). N = 19 WT and 18 St18 cKO. b Quantification of Nkx2-1+ neurons (Unpaired t-test). N = 11 WT and 12 St18 cKO. c Quantification of Er81+ neurons (Unpaired t-test). N = 20 WT and 18 St18 cKO. d Schematic representation of adult mouse brain in the parasagittal plane showing axonal projections of GPe prototypic neurons (orange) targeting the STN (blue). e WT and St18 cKO STN (outlined in blue) with MGE lineage whole cell labeled fate map (Nkx2-1Cre; Ai9). Quantification of axonal innervation area (Unpaired t-test). N = 9 WT and 27 St18 cKO. f WT and St18 cKO STN with (left) MGE lineage synaptophysin labeled fate map (Nkx2-1Cre; Ai34). tdTomato, (right) 3D segmented puncta quantified for puncta density and puncta size (Unpaired t-test). N = 27 WT and 12 St18 cKO. Data are presented as mean +/− SEM. Source data are provided as a Source data file. Scale bars: a–c, e 500 microns; f 100 microns.
