Fig. 6: Single-cell RNA-seq reveals that specific neuronal clusters are differentially produced upon St18 genetic ablation.
From: St18 specifies globus pallidus projection neuron identity in MGE lineage
a UMAP visualization of 14 progenitor clusters identified in WT (left) and St18 (−/−) (St18 (−/−), right) e14.5 MGE. b UMAP visualization of 22 neuronal clusters identified in WT (left) and St18 (−/−) e14.5 MGE. Relative proportions of each c progenitor cluster and d neuronal clusters, biological replicates plotted separately. WT replicates 1 and 2 in shades of blue, St18 (−/−) replicates 1 and 2 in shades of purple. e Dot plot showing scaled average expression of differentially-expressed genes in neuron clusters 2, 4, and 5. Numbers indicated on UMAP visualizations in (a) and (b) denote clusters with the most pronounced alterations in proportional representation between WT and St18 (−/−). scRNA-seq dataset represents 2 biological replicates per genotype, 8143 WT cells and 9922 St18 (−/−) cells that passed quality control total.
