Fig. 1: BOLD fMRI signals associated with SWDs in GAERS resemble human absence epilepsy. | Nature Communications

Fig. 1: BOLD fMRI signals associated with SWDs in GAERS resemble human absence epilepsy.

From: Decreased but diverse activity of cortical and thalamic neurons in consciousness-impairing rodent absence seizures

Fig. 1

a Statistical Parametric Mapping (SPM) analysis of spike-wave discharge (SWD)-associated changes in blood-oxygen-level-dependent (BOLD) signal. Cortex shows mainly functional magnetic resonance imaging (fMRI) decreases (cool colors), whereas the thalamus shows fMRI increases (warm colors). Values on both color scales indicate the magnitude of increases (upper scale) and decreases (lower scale). T maps are superimposed on coronal anatomical images from the template animal, with FDR corrected threshold p < 0.05. AP coordinates are in millimeters relative to bregma91. b Regions of interest overlaid on a reference anatomical MRI image. Structures are taken from the Paxinos & Watson Rat Brain Atlas91 after alignment of image sections with approximate rostrocaudal locations from bregma. Somatosensory cortex (ctx, cyan) includes all S1 regions from bregma +1 mm to bregma −3.6 mm; Ventrobasal thalamus (thal, orange) includes VPM and VPL from bregma −2.3 mm to bregma −4.16 mm. Note that these are representative sections only and do not constitute the full extent of the regions in question. c Mean percent-change time courses of BOLD signals (±SEM) in each of the regions described in b (including medial (pink) and lateral (green) caudate putamen (CPU)) aligned to SWD onset and offset in 1 s time bins. N = 18 animals, 670 SWDs in all of these analyses.

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