Fig. 4: Synthetic utility.
From: Ni-catalyzed benzylic β-C(sp3)–H bond activation of formamides
a Reaction of substrates bearing bioactive structural motifs under the optimal conditions with varying amounts of AlEt3. †AlEt3 (80 mol%). ‡AlEt3 (100 mol%). b Gram-scale reaction and product transformations. TFA = trifluoroacetic acid. DMEDA = N,N’-dimethyl-1,2-ethanediamine. Boc2O = di(tert-butyl)carbonate. DMAP = 4-dimethylamino pyridine. BINOL = (rac)−1,1’-bi(2-naphthol). NaBArF4 = sodium tetrakis(perfluorophenyl)borate.
