Table 1 Summary of drug clearance experiments
From: Large-scale perfused tissues via synthetic 3D soft microfluidics
Compound | Enzyme | Turnover | Predicted clearance (ml/min/kg) | Observed clearance (ml/min/kg) | Fold prediction error (FPE) (predicted/observed) |
|---|---|---|---|---|---|
Quinidine | CYP3A4 | Intermediate | 10 | 4.7 | 2.1 |
Metoclopramide | CYP2D6 | Intermediate | 1.5 | 6.2 | 0.2 |
Theophylline | CYP1A2 | Slow | 0.8 (1.5) | 0.77 | 1.0 (1.9) |
