Fig. 8: Disruption of astrocytic CB1R-mediated signaling impairs formation of spatial memory. | Nature Communications

Fig. 8: Disruption of astrocytic CB1R-mediated signaling impairs formation of spatial memory.

From: An astrocytic signaling loop for frequency-dependent control of dendritic integration and spatial learning

Fig. 8

a Schematic arena for testing object location memory. Two identical objects (red squares) are explored by the animals (10 min) during acquisition. During testing, one object is moved to a new location and mice are allowed for freely explore the objects (5 min). b Total exploration time did not differ between sham control animals and animals with conditional deletion of CB1Rs in astrocytes (aCB1KO) (7.78 ± 2.07 s vs. 5.30 ± 0.69 s, n = 10 and 12 animals, p = 0.54, two-sided Mann–Whitney U-test). c Sham control mice explored the object in the novel location significantly more whereas aCB1KO mice did not discriminate (0.30 ± 0.10 vs. −0.09 ± 0.09, n = 10 and 12 animals, p = 0.0098, two-sided Student’s t test). Data are displayed in box plots, in which the box indicates the 25th and 75th, the whiskers the 5th and 95th percentiles, the horizontal line in the box the median and the mean is represented by a filled circle. Source data are provided as a Source Data file.

Back to article page