Table 3 Echocardiographic data for Lmna^{p.H222P/H222P} (H222P) mice treated with tubastatin A or DMSO at 2, 2.5, and 3 months of age

Age

2 months

2 months

2.5 months

2.5 months

3 months

3 months

n

5

6

5

6

5

6

Time (ms)

99.83 ± 1.65

100.4 ± 1.75

101.0 ± 1.56

100.4 ± 1.72

102.3 ± 2.09

100.7 ± 1.35

Heart rate (bpm)

601.7 ± 9.96

598.3 ± 10.14

594.5 ± 9.31

598.7 ± 10.25

587.4 ± 11.93

596.4 ± 7.94

Cardiac output (l/min)

0.06 ± 0.007

0.07 ± 0.002

0.07 ± 0.002

0.06 ± 0.003

0.06 ± 0.005

0.06 ± 0.003

IVSd (cm)

0.07 ± 0.002

0.07 ± 0.02

0.07 ± 0.001

0.07 ± 0.001

0.07 ± 0.002

0.07 ± 0.001

LVDd (cm)

0.37 ± 0.01

0.37 ± 0.004

0.39 ± 0.002

0.37 ± 0.004

0.39 ± 0.009

0.37 ± 0.003

LVPWd (cm)

0.07 ± 0.003

0.07 ± 0.003

0.06 ± 0.003

0.07 ± 0.003

0.07 ± 0.004

0.06 ± 0.002

IVSs (cm)

0.12 ± 0.004

0.12 ± 0.002

0.11 ± 0.002

0.11 ± 0.002

0.11 ± 0.004

0.11 ± 0.003

LVDs (cm)

0.21 ± 0.006

0.21 ± 0.004

0.24 ± 0.004

0.19 ± 0.004****

0.26 ± 0.008

0.22 ± 0.005****

LVPWs (cm)

0.0 ± 0.004

0.11 ± 0.003

0.09 ± 0.004

0.11 ± 0.003

0.08 ± 0.002

0.10 ± 0.005*

LVED vol (ml)

0.13 ± 0.11

0.13 ± 0.004

0.15 ± 0.003

0.12 ± 0.003

0.16 ± 0.01

0.12 ± 0.005

LVES vol (ml)

0.02 ± 0.003

0.02 ± 0.002

0.04 ± 0.002

0.02 ± 0.001**

0.05 ± 0.005

0.03 ± 0.003**

EF (%)

82.9 ± 0.46

82.45 ± 0.52

75.33 ± 0.39

82.90 ± 0.58***

70.18 ± 2.01

78.81 ± 1.11****

FS (%)

45.65 ± 1.06

45.25 ± 0.55

38.43 ± 0.33

45.68 ± 0.63****

34.42 ± 1.51

41.60 ± 1.03****

LV eject vol (ml)

0.10 ± 0.009

0.11 ± 0.002

0.11 ± 0.002

0.10 ± 0,003

0.11 ± 0.007

0.10 ± 0.003

h/r

0.37 ± 0.006

0.35 ± 0.008

0.34 ± 0.007

0.38 ± 0.005*

0.35 ± 0.008

0.36 ± 0.004