Fig. 4: Impact of Omicron mutations on neutralizing activity of the three representative nanobodies. | Nature Communications

Fig. 4: Impact of Omicron mutations on neutralizing activity of the three representative nanobodies.

From: Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses

Fig. 4

a Binding modes of 1-2C7 (orange), Nb70 (green), and 3-2A2-4 (purple) to prototype SARS-CoV-2 RBD with the relevant major mutation sites found in Omicron subvariants highlighted in red. b‒d The footprints of 1-2C7 (orange), Nb70 (green), and 3-2A2-4 (purple) on the surface of prototype SARS-CoV-2 RBD (cyan), relative to relevant major mutation sites found in Omicron subvariants highlighted in red. e‒g Neutralizing activity of 1-2C7 Fc, Nb70 Fc, and 3-2A2-4 Fc against pseudoviruses bearing the indicated mutations found in Omicron subvariants. Data are presented as the means ± SD from three independent experiments. Source data e–g are provided as a Source Data file.

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