Fig. 6: SSM-PEG (PEG-modified SPIO@SiO2@MnO2) for MRI trace of tiny liver metastases in vivo.
From: A pH-responsive T1-T2 dual-modal MRI contrast agent for cancer imaging
a Illustration of the construction and MRI diagnosis processes of the metastatic model. b T1 and T2 map images and c R1 and R2 at the liver metastasis of the mice before I.V. injection and 2 h after the injection of SSM-PEG. T1 and T2 Map are representative data from three mice samples. R1 and R2 Data are presented as mean ± SD from three independent mice samples. d T1 and T2 dual-modal MRI images of the liver metastasis were processed by DESI method, which were taken without the use of contrast agent and 2 h after the injection of SSM-PEG. Representative data are shown from three mice samples. e Ex vivo image of the liver with a tiny metastasis. Representative data are shown from three mice samples. f H&E stain of the slices of the liver metastasis. Representative data are shown from three mice samples. g TNR quantified from the DESI processed images in d and e. Data are presented as mean ± SD from three independent mice samples. The two-tailed Student’s t-test is employed for the statistical analysis. *P < 0.05; **P < 0.01; ***P < 0.001. Source data are provided as a Source Data file.
